血栓反应素
银屑病
真皮
去整合素
免疫组织化学
黑素细胞
表皮(动物学)
金属蛋白酶
病理
黑色素
生物
医学
癌症研究
免疫学
基质金属蛋白酶
黑色素瘤
解剖
内科学
遗传学
作者
Kathleen M. Bonifacio,Norma Kunjravia,James G. Krueger,Judilyn Fuentes‐Duculan
出处
期刊:Journal of Pigmentary Disorders
[OMICS Publishing Group]
日期:2016-01-01
卷期号:3 (3)
被引量:34
标识
DOI:10.4172/2376-0427.1000244
摘要
A Disintegrin-like and Metalloprotease domain containing Thrombospondin type 1 motif-like 5 (ADAMTSL5) is a melanocyte-derived protein that has recently been implicated as an activating antigen for IL-17-producing T cells in psoriasis. There is a potential disconnect between the basal location of the melanocytes in the epidermis and the fact that T-cell infiltrates are seen mostly scattered in the epidermis with very large infiltrates in the dermis. Thus, we hypothesized that ADAMTSL5 may be expressed in other cells aside from melanocytes in skin. To further investigate the cutaneous expression of ADAMTSL5, we performed immunohistochemistry staining on lesional and nonlesional skin biopsies from psoriasis patients using three different commercially available antibodies. We confirmed that all ADAMTSL5 antibodies reacted with epidermal melanocytes. However, we also observed a strong expression of this protein in keratinocytes throughout the epidermis, and scattered expression in some dermal blood vessels and other perivascular dermal cells. Overall, the pattern of ADAMTSL5 expression is very similar to the infiltrating pattern of T-cells and dendritic cells in psoriasis lesions.
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