医学
第三代
耐受性
药代动力学
第一代
药理学
不利影响
计算机科学
电信
环境卫生
人口
作者
Bin Zhang,Yanli Wang,Yanhua Chen,Fred Yang
标识
DOI:10.1093/ofid/ofw172.1544
摘要
Background.KBP-7072 is a novel aminomethylcycline exhibiting broad-spectrum activity against Gram+ and Gram-multidrug resistant bacterial isolates and strains.Methods.This was a randomized, double-blind, placebo-controlled, sequential parallel group, single ascending dose study in healthy adults to evaluate the safety, tolerability, and pharmacokinetics (PK) of KBP-7072 following oral administration and with an open label food effect panel.Under fasting conditions, 5 fasting cohorts (30 mg, 100 mg, 300 mg, 600 mg, and 1000 mg) were planned with 8 subjects (6 KBP-7072; 2 placebo) in each cohort.Dose escalation stopped following the 300 mg cohort.An additional 6 subjects received a single oral dose (100 mg) under fed conditions.
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