PI3K/AKT/mTOR通路
蛋白激酶B
LY294002型
芒柄花素
神经毒性
化学
活力测定
淀粉样前体蛋白
细胞毒性
细胞生物学
细胞凋亡
β淀粉样蛋白
信号转导
药理学
癌症研究
生物化学
阿尔茨海默病
生物
医学
内科学
毒性
体外
肽
大豆黄酮
疾病
染料木素
有机化学
作者
Lizhi Chen,Shanshan Ou,Lingqi Zhou,Hai Tang,Jie Xu,Guo Ke
标识
DOI:10.1016/j.neulet.2016.12.064
摘要
Amyloid beta (Aβ) is the main component of the amyloid plaques that accumulate in the brains of Alzheimer patients. Here, we reported the protective role of Formononetin (Form) against Aβ25-35-induced neurotoxicity in HT22 cells. We found that Form significantly increased the viability of HT22 cells but decreased the cell apoptosis when challenging with Aβ25-35. The inhibitory effects of Form were associated with PI3K/Akt signaling pathway as PI3K inhibitor (LY294002) or ERα specific inhibitor (MPP) blocked the effects. Form also accelerated the non-amyloidogenic process of amyloid precursor protein (APP) by enhancing α-secretase activity and sAPPα release. Altogether, our findings may provide a novel therapeutic target to treat AD sufferers.
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