The Benefits of Exercise and Metabolic Interventions for the Prevention and Early Treatment of Alzheimer's Disease

Background: Alzheimer's disease (AD) is characterized by neuronal degeneration, vascular pathology and cognitive decline. Furthermore, deficits in cerebral glucose metabolism and insulin resistance are being increasingly recognized in AD. Many lifestyle-modifying approaches, including diet and exercise, have yielded promising results in modulating brain morphology and function for the prevention and early treatment of AD. Keywords: Diabetes mellitus, insulin, metabolism, neurogenesis, physical activity, plasticity.