医学
髓系白血病
白血病
威尼斯人
抗体
癌症研究
免疫学
肿瘤科
内科学
慢性淋巴细胞白血病
作者
Steven R. Leong,Siddharth Sukumaran,Maria Hristopoulos,Klára Tótpál,Shannon Stainton,Elizabeth Lu,Alfred Wong,Lucinda Tam,Robert G. Newman,Brian R. Vuillemenot,Diego Ellerman,Cheng Gu,Mary Mathieu,Mark S. Dennis,Allen Nguyen,Bing Zheng,Crystal Zhang,Genee Lee,Yu‐Waye Chu,Rodney A. Prell,Kedan Lin,Steven T. Laing,Andrew G. Polson
出处
期刊:Blood
[Elsevier BV]
日期:2017-02-02
卷期号:129 (5): 609-618
被引量:121
标识
DOI:10.1182/blood-2016-08-735365
摘要
Key Points Bispecific antibodies binding CD3 and CLL-1 deplete CLL-1+ target cells in animal models. An appropriately engineered CLL-1/CD3 bispecific antibody could be effective in treating AML.
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