合成大麻素
大麻素
头发分析
大麻
滥用药物
化学
受影响驾驶
法医毒理学
大麻酚
大麻素受体
大麻的影响
药理学
大麻酚
设计药物
色谱法
毒物控制
药品
医学
伤害预防
生物化学
受体
精神科
替代医学
兴奋剂
病理
环境卫生
作者
Byungsuk Cho,Han Soo Cho,Jung-Hyun Kim,Juhyun Sim,Ilung Seol,Seung Kyung Baeck,Sangwhan In,Dae Hwan Shin,Eun‐Mi Kim
标识
DOI:10.1016/j.forsciint.2019.110058
摘要
Hair is one of the key samples for judging drug abuse in the field of forensic science. However, few studies have examined synthetic cannabinoids and their metabolites in human hair. Synthetic cannabinoids are a class of chemicals that bind to cannabinoid receptors, but they differ structurally from the cannabinoids found in cannabis. They have been sold sprayed on dried, shredded plant material under brand names such as "Spice" since the 2000s. In South Korea, synthetic cannabinoids have been widely distributed since 2009 and many types detected up to now. Unlike traditional drugs such as methamphetamine and cannabis, the abuse trends of synthetic cannabinoids were variable by regions and changed according to the times. If new types of synthetic cannabinoids become popular which has been altered in some structures, it becomes difficult to identify using exist analytical method. Therefore, it is important to develop a new analytical method for synthetic cannabinoids currently being abused in society. In this study, we developed simultaneous analytical methods for the detection of 18 synthetic cannabinoids and 41 of their metabolites in authentic human hair samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Selectivity, linearity, limits of detection (LODs), limits of quantification (LOQs), precision, accuracy, matrix effect, recovery, and process efficiency were evaluated, and all results were acceptable. Additionally, the distribution of synthetic cannabinoids in the head hair of Korean drug abusers from 2016 to 2018 was investigated. Hair samples from 43 individuals suspected of synthetic cannabinoid use were provided by law enforcement agencies. The drugs detected most prevalently in the head hair of Korean drug abusers were AB-CHMINACA and JWH-210.
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