ISG15
寨卡病毒
生物
干扰素刺激基因
病毒学
干扰素
病毒复制
JAK-STAT信号通路
病毒
小头畸形
基因
免疫学
信号转导
遗传学
先天免疫系统
免疫系统
酪氨酸激酶
泛素
作者
Yancui Wang,Kai Ren,Shilin Li,Chunhui Yang,Limin Chen
出处
期刊:Virus Research
[Elsevier]
日期:2020-07-29
卷期号:287: 198087-198087
被引量:13
标识
DOI:10.1016/j.virusres.2020.198087
摘要
Zika virus is an emergent arbovirus that has caused a public health emergency in South America. Zika virus infection is known to cause microcephaly and other congenital defects and Guillain-Barré syndrome. Unfortunately no direct antiviral treatments are available at present. IFN-stimulated gene 15 (ISG15) is one of the most upregulated host genes following type I interferon treatment or virus infections. ISG15 has been shown to have antiviral effect on a wide variety of viruses although pro-HCV replication was observed. However, the effect of ISG15 on ZIKV infection is not well defined. In this study, we try to clarify the effect of ISG15 on ZIKV replication and to further dissect the underlying mechanism. Our results indicated that ZIKV infection led to the increased expression of ISG15 in A549, 2fTGH, U5A cells. Overexpression of ISG15 stimulated ZIKV replication although ISG15 did not affect the viral entry. Further studies showed that this proviral effect was mediated through Jak/STAT signaling pathway and was ISGylation-dependent. Taken together, our work demonstrates that ISG15 is an important host factor exploited by ZIKV to facilitate its replication and might serve as a potential target for the development of novel antiviral agents.
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