生物矿化
氧烷
生物相容性
材料科学
扩展X射线吸收精细结构
矿化组织
钙
磷酸丝氨酸
吸收(声学)
纳米技术
生物物理学
化学工程
矿物学
吸收光谱法
化学
光谱学
生物化学
牙本质
生物
丝氨酸
物理
工程类
复合材料
酶
冶金
量子力学
作者
Hong Zhou,Yingying Jiang,Shuo Tan,Li-Jia Liu,Qianting Yao,Yujian Xia,Yunshan Fan,Jianping Hu,Zifei Zhou,Bing‐Qiang Lu,Shisheng He,Feng Chen
标识
DOI:10.1016/j.ceramint.2020.05.142
摘要
Biomineralization is a set of processes whereby living organisms generate hierarchically structured organic–inorganic materials. Studies on biomineralization not only elucidate the natural process of biomineral formation but also contribute to the development of functional biomaterials. However, the function of small molecules in the process has not been clarified. In this study, phosphoserine (PS) was used as a phosphorus source to prepare biomimetic minerals, and a new flower-like organic–inorganic complex of calcium PS (CaPS) was obtained. The CaPS samples were self-assembled plate-like crystals in the first 10 min. Then, over the next 5 h of the reaction, the plate-like crystals were broken down into fine granular nanoparticles. The chemical and thermal properties of CaPS were characterized, and the results indicated that the CaPS was or had a similar structure to Ca(C3H6NO6P)·H2O. X-ray absorption near edge structure (XANES) and extended X-ray absorption fine structure spectra (EXAFS) were obtained, which clearly revealed 6-fold-coordinated Ca-O bonds with lengths of 2.319 (±0.0147) Å, 2.358 (±0.0147) Å, and 2.435 (±0.0147) Å. Furthermore, the results of a CCK-8 assay indicated the high biocompatibility of CaPS. When the samples were co-cultured with mouse preosteoblast cells (MC3T3-E1), CaPS exhibited good bioactivity to promote the osteoblast differentiation of cells. Owing to its excellent chemical and biological properties, the as-prepared CaPS complex is promising for various biomedical applications.
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