抗菌活性
细菌
膜
化学
大肠杆菌
粒径
膜透性
生物物理学
金黄色葡萄球菌
微生物
革兰氏阴性菌
微生物学
生物
生物化学
物理化学
基因
遗传学
作者
Baohong Sun,Fan Wu,Qicheng Zhang,Xiaohong Chu,Zhixuan Wang,Xinrong Huang,Jie Li,Cheng Yao,Ninglin Zhou,Jian Shen
标识
DOI:10.1016/j.jcis.2020.10.015
摘要
Carbon dots (CDs) have a profound effect on elimination of bacteria, fungi, and viruses, but the lack of an exact mechanism to interact with bacterial cells limits their development. Herein, we separated the CDs derived from chlorhexidine gluconate into three groups with uniformly small-scale, middle-scale, and large-scale particle sizes by using different molecular weight cut-off membranes. These positively charged particles exhibit significant antibacterial activity against the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus; they can cause an increase in bacterial cell permeability, synergistic destabilization, and broken integrity of the plasma membrane. Impressively, we found that antibacterial activity increases as the size of the CDs decreases. This phenomenon may stem from the differences in cellular uptake and distribution of CDs in the plasma membrane or restriction between the polar functional group and DNA molecule. Our study of the size effect as a target may improve the understanding of killing microorganisms by antibacterial CD drugs.
科研通智能强力驱动
Strongly Powered by AbleSci AI