药剂师
皮肤癌
医学
皮肤病科
光化性角化病
药物输送
局部用药
癌症
纳米技术
基底细胞
病理
内科学
材料科学
作者
Miko Yamada,Tarl W. Prow
标识
DOI:10.1016/j.addr.2020.04.008
摘要
This review analyses physical drug delivery enhancement technologies with a focus on improving UV damaged skin, actinic keratoses and non-melanoma skin cancer treatment. In recent years, physical drug delivery enhancement has been shown to enhance cosmeceutical and skin cancer treatment efficacy, but there are pros and cons to each approach which we discuss in detail. Mechanisms of action, clinical efficacy, experimental design, outcomes in academic publications, clinical trial reports and patents are explored to evaluate each technology with a critical, translation focused lens. We conclude that the commercial success of cosmeceutical applications, e.g. microneedles, will drive further innovation in this arena that will impact how actinic keratoses and non-melanoma skin cancers are clinically managed.
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