脂质过氧化
GPX4
氧化应激
4-羟基壬醛
程序性细胞死亡
细胞内
平衡
细胞生物学
谷胱甘肽
生物
活性氧
化学
生物化学
神经科学
谷胱甘肽过氧化物酶
酶
超氧化物歧化酶
细胞凋亡
作者
Cadiele Oliana Reichert,Fábio Alessandro de Freitas,Juliana Sampaio-Silva,Leonardo Rokita-Rosa,Priscila de Lima Barros,Débora Levy,Sérgio Paulo Bydlowski
摘要
Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential as a redox metal in several physiological functions. The brain is one of the organs known to be affected by iron homeostatic balance disruption. Since the 1960s, increased concentration of iron in the central nervous system has been associated with oxidative stress, oxidation of proteins and lipids, and cell death. Here, we review the main mechanisms involved in the process of ferroptosis such as lipid peroxidation, glutathione peroxidase 4 enzyme activity, and iron metabolism. Moreover, the association of ferroptosis with the pathophysiology of some neurodegenerative diseases, namely Alzheimer’s, Parkinson’s, and Huntington’s diseases, has also been addressed.
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