骨骼肌
内科学
内分泌学
碳水化合物代谢
糖原
新陈代谢
葡萄糖稳态
胰岛素抵抗
葡萄糖摄取
胰岛素
平衡
肌病
生物
医学
出处
期刊:Intern J Endocrinol Metab
日期:2009-03-20
卷期号:29 (02): 104-106
标识
DOI:10.3760/cma.j.issn.1673-4157.2009.02.010
摘要
Skeletal muscle is the principal site of glucose uptake under insulin-stimulated conditions,and it plays an important role in the glucose homeostasis. Under pathological state, the regulation of skeletal muscle on glucose metabolism is decreased. Muscle glycogen and the circulation glucose are essential for the physiological metabolism and function of skeletal muscle. The glucose metabolic disturbance, especially hyperglycemia, has profound impact on the skeletal muscle with regard to dysfunction, metabolic disturbance and structural changes, including insulin resistance, muscle glycogen metabolic disturbance, myatrophy and vascular abnormality. Myopathy may affect metabolism in turn,which may worsen the pathogenetic condition.
Key words:
Skeletal muscle; Glucose metabolism; Hyperglycemia; Muscular diseases
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