Synthesis, spectroscopic and biological activity evaluation of Ni(II), Cu(II) and Zn(II) complexes of schiff base derived from pyridoxal and 4-fluorobenzohydrazide

席夫碱 八面体分子几何学 化学 赫拉 金属 核化学 吡哆醛 抗菌活性 对接(动物) 配体(生物化学) 立体化学 结晶学 细菌 生物化学 体外 生物 有机化学 医学 护理部 受体 遗传学 磷酸盐
作者
R Kavitha,Ch. Venkata Reddy,B. Sireesha
出处
期刊:Nucleosides, Nucleotides & Nucleic Acids [Taylor & Francis]
卷期号:40 (8): 845-866 被引量:3
标识
DOI:10.1080/15257770.2021.1961271
摘要

A novel Schiff base ligand, 4-fluoro-N-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)benzohydrazide (PLFBH) was synthesized by condensationof pyridoxal and 4-fluorobenzohydrazide. Its complexes with Ni(II), Cu(II), and Zn(II) metal ionswere prepared and characterized by spectroscopic IR, 1H-NMR, UV, LC-MS, ESR, and powder XRD studies and by elemental analysis and thermal analysis, molar conductance, and magnetic susceptibility measurements. The results indicate the geometry of the complexes to be hexa coordinate distorted octahedral. Based on the electronic absorption and fluorescence emission spectra and viscosity studies, an intercalative mode of binding of the complexes with CT-DNA was suggested, which was also supported by DNA docking studies. The docking studies of metal complexes with DNA were carried out using Autodock 4.2. The in vitro anticancer assay for the Cu(II)-PLFBH complex was performed to assess the ability of the complex to inhibit human cell proliferation on HeLa human cervical carcinoma cells, MCF-7 human breast carcinoma cells, and A549 human lung carcinoma cells. The Cu(II)-PLFBH complex exhibited moderate to good inhibitory effect on the cancer cell lines studied. The complexes showed good cleavageability toward plasmid pBR322 DNA. The metal complexes were found to show good antibacterial activity against gram positive bacteria, Staphylococcus aureus and Bacillus cereus and gram negative bacteria Escherichia coli and Pseudomonas aeruginosa cultures,while the ligand showed marginal activity.Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1961271 .
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
loski发布了新的文献求助10
1秒前
慕青应助故晨采纳,获得10
1秒前
汉堡包应助那咋了采纳,获得10
2秒前
2秒前
3秒前
果果瑞宁发布了新的文献求助10
4秒前
4秒前
坦率的匪应助科研通管家采纳,获得10
4秒前
4秒前
bkagyin应助科研通管家采纳,获得50
4秒前
4秒前
March应助科研通管家采纳,获得10
4秒前
FashionBoy应助科研通管家采纳,获得10
4秒前
5秒前
5秒前
领导范儿应助科研通管家采纳,获得10
5秒前
天天快乐应助科研通管家采纳,获得10
5秒前
充电宝应助科研通管家采纳,获得10
5秒前
5秒前
5秒前
CodeCraft应助llll采纳,获得10
5秒前
5秒前
5秒前
在水一方应助科研通管家采纳,获得10
5秒前
科研通AI5应助科研通管家采纳,获得30
5秒前
英姑应助科研通管家采纳,获得10
5秒前
猪猪hero应助科研通管家采纳,获得10
5秒前
猪猪hero应助科研通管家采纳,获得10
5秒前
5秒前
斯文败类应助科研通管家采纳,获得10
5秒前
华仔应助tp040900采纳,获得10
5秒前
奋斗雁山发布了新的文献求助10
6秒前
鸭梨发布了新的文献求助10
7秒前
Bella发布了新的文献求助10
7秒前
7秒前
旭a完成签到,获得积分10
8秒前
隐形曼青应助feizhuliu采纳,获得10
8秒前
9秒前
keke完成签到,获得积分10
9秒前
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988827
求助须知:如何正确求助?哪些是违规求助? 3531197
关于积分的说明 11252739
捐赠科研通 3269830
什么是DOI,文献DOI怎么找? 1804815
邀请新用户注册赠送积分活动 881915
科研通“疑难数据库(出版商)”最低求助积分说明 809028