功能训练
免疫系统
随机对照试验
医学
心肺适能
CD28
CD8型
内科学
物理疗法
免疫学
作者
José Carlos Aragão-Santos,Alan Bruno Silva Vasconcelos,Antônio Gomes de Resende–Neto,Lorranny Santana Rodrigues,Nathanielly de Lima Silva,Danilo Nobre da Silva,Dulce Marta Schimieguel,Cristiane Bani Corrêa,Marzo Edir Da Silva‐Grigoletto
标识
DOI:10.1016/j.exger.2021.111504
摘要
To evaluate the effects of functional and concurrent training on immune function and functional fitness in postmenopausal women. A randomized controlled trial was performed on 108 women aged 60 or older who were randomly assigned among the groups: control group (CG: n = 40; 63.88 ± 3.64 years); functional training (FT: n = 32; 63.88 ± 3.79 years); and concurrent training (CT: n = 36; 64.83 ± 4.00 years). Immune function was measured by the expression of the T-lymphocyte function-related surface markers (CD28 and CD57). Functional fitness was assessed using physical tests similar to daily activities, i.e., five times sit to stand, timed up and go, and gallon-jug shelf-transfer. Regarding immune function, there was only a time effect, without between-group differences. Specifically, FT and CT show a reduction and increase in CD4+ and CD8+ T cells, respectively, without impairment in the subpopulations analyzed, while CG showed a reduction in naive T cells (CD8+CD28+). For functional fitness tests, there was a time × group interaction effect for all tests, the FT and CT were superior to the CG, with FT showing differences after the fourth week, while the CT showed this effect after the eighth week of intervention. FT and CT do not impair immune function and similarly improve functional fitness in postmenopausal women. RBR-2d56bt.
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