Ligand-Free Iron-Catalyzed Intramolecular Amination of C(sp3)—H Bond for the Synthesis of Imidazolinones

Transition-metal-nitrenoids intramolecular C-H insertion is one of the most effective methods to synthesize nitrogen-containing heterocycles.Using 2-azido-N,N-dibenzylacetamides as substrates, an iron-catalyzed intramolecular C(sp 3 )-H bond amination reaction under ligand-free and external oxidant-free conditions has been developed.A series of imidazolinones were synthesized in moderate to good yields.