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Serum concentrations of per-/polyfluoroalkyl substances and risk of type 2 diabetes: A case-control study

医学 2型糖尿病 环境化学 环境卫生 糖尿病 环境科学 化学 内分泌学
作者
Yishuang Duan,Hongwen Sun,Yiming Yao,Yongcheng Li,Yue Meng,Yuan Lü,Liping Han,Liming Chen
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:787: 147476-147476 被引量:18
标识
DOI:10.1016/j.scitotenv.2021.147476
摘要

Per-/polyfluoroalkyl substances (PFASs), as a group of synthetic chemicals, have been extensively detected in human samples. Recently, epidemiological investigations have reported relationships between exposure to PFASs with risk of type 2 diabetes mellitus (T2DM), but with contradictory results. In this study, a case-control study was conducted to explore associations between serum PFASs and T2DM risk among 252 T2DM cases and 252 controls, who were both diagnosed according to fasting glucose and glycosylated hemoglobin levels. Besides, dose-response relationships were analyzed to clarify effects of PFAS exposure on T2DM risk at different exposure levels. Multivariable logistic regression models showed that compared to the lowest tertiles, elevated odds of T2DM risk were observed in the middle tertiles of perfluorohexane sulfonic acid (PFHxS) [odds ratio (OR): 4.09; 95% confidence interval (CI): 2.23, 7.50; p < 0.01] and perfluorohexane sulfonic acid (PFHpA) (OR: 1.87; 95% CI: 1.06, 3.29; p = 0.03), but not in the highest tertiles, and the restricted cubic spline regression models presented inverted U-shaped dose-response relationships for exposure to PFHxS and PFHpA with T2DM risk, indicating non-monotonic dose-response effect and low-dose effect. Most other PFASs were inversely associated with risk of T2DM, especially at higher exposure levels. Our findings suggested that there are associations between exposure to PFASs and risk of T2DM. Further mechanism research is worthy to be conducted to elucidate the mode of action of different PFASs on T2DM at different exposure levels. • Serum PFHxS is significantly positively related to T2DM risk at lower levels. • Serum PFHpA is significantly positively related to T2DM risk at lower levels. • Inverted U-shaped dose-response relationship is observed for serum PFHxS and T2DM. • Inverted U-shaped dose-response relationship is observed for serum PFHpA and T2DM. • Most serum PFASs show negative associations with T2DM risk in the highest tertiles.
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