相互作用体
细胞骨架
肌动蛋白
树突棘
神经科学
微管
肌动蛋白细胞骨架
细胞生物学
生物
神经突
突触可塑性
细胞
生物化学
体外
受体
基因
海马结构
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2021-03-19
卷期号:49 (2): 685-692
被引量:7
摘要
Drebrin is a key regulator of actin cytoskeleton in neuronal cells which is critical for synaptic plasticity, neuritogenesis, and neuronal migration. It is also known to orchestrate a cross-talk between actin and microtubules. Decreased level of drebrin is a hallmark of multiple neurodegenerative disorders such as Alzheimer's disease. Despite its established importance in health and disease, we still have a lot to learn about drebrin's interactome and its effects on cytoskeletal dynamics. This review aims to summarize the recently reported novel effects of drebrin on actin and its regulators. Here I will also reflect on the most recent progress made in understanding of the role of drebrin isoforms and posttranslational modifications on its functionality.
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