微生物群
胃肠道
益生菌
炎症
医学
肠道菌群
失调
氧化应激
酒
病态的
免疫学
肠道微生物群
疾病
内科学
生物
生物信息学
细菌
生物化学
遗传学
作者
Phillip Engen,Stefan J. Green,Robin M. Voigt,Christopher B. Forsyth,Ali Keshavarzian
出处
期刊:PubMed
日期:2015-01-01
卷期号:37 (2): 223-36
被引量:231
摘要
The excessive use of alcohol is a global problem causing many adverse pathological health effects and a significant financial health care burden. This review addresses the effect of alcohol consumption on the microbiota in the gastrointestinal tract (GIT). Although data are limited in humans, studies highlight the importance of changes in the intestinal microbiota in alcohol-related disorders. Alcohol-induced changes in the GIT microbiota composition and metabolic function may contribute to the well-established link between alcohol-induced oxidative stress, intestinal hyperpermeability to luminal bacterial products, and the subsequent development of alcoholic liver disease (ALD), as well as other diseases. In addition, clinical and preclinical data suggest that alcohol-related disorders are associated with quantitative and qualitative dysbiotic changes in the intestinal microbiota and may be associated with increased GIT inflammation, intestinal hyperpermeability resulting in endotoxemia, systemic inflammation, and tissue damage/organ pathologies including ALD. Thus, gut-directed interventions, such as probiotic and synbiotic modulation of the intestinal microbiota, should be considered and evaluated for prevention and treatment of alcohol-associated pathologies.
科研通智能强力驱动
Strongly Powered by AbleSci AI