化学
对映选择合成
铱
胺化
对映体
催化作用
配体(生物化学)
烯丙基重排
组合化学
烯丙醇
酒
立体化学
有机化学
受体
生物化学
作者
Ting Lei,Hongbin Zhang,Yu‐Rong Yang
标识
DOI:10.1016/j.tetlet.2015.09.039
摘要
A new protocol for generating indoleazepine 9 via an Ir-catalyzed intramolecularly asymmetric amination of secondary allylic alcohol 5 in the presence of Carreira ligand (10) and Sc(OTf)3 is described. This methodology has been exploited in the facile synthesis of natural (−)-aurantioclavine (1), a biosynthetical precursor of communesins, and its unnatural enantiomer (+)-aurantioclavine (ent-1).
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