丙酮酸脱氢酶复合物
丙酮酸脱氢酶磷酸酶
二氢脂酰胺脱氢酶
丙酮酸脱氢酶激酶
酮戊二酸脱氢酶复合物
酰基转移酶
生物化学
二氢脂酰转乙酰酶
支链α-酮酸脱氢酶复合物
脱氢酶
丙酮酸脱羧酶
酰基转移酶
丙酮酸脱羧
丙酮酸脱氢酶脂酰胺激酶同工酶1
生物
化学
酶
醇脱氢酶
生物合成
作者
Brian Mooney,Ján A. Miernyk,Douglas D. Randall
标识
DOI:10.1146/annurev.arplant.53.100301.135251
摘要
▪ Abstract Plant cells are unique in that they contain four species of α-ketoacid dehydrogenase complex: plastidial pyruvate dehydrogenase, mitochondrial pyruvate dehydrogenase, α-ketoglutarate (2-oxoglutarate) dehydrogenase, and branched-chain α-ketoacid dehydrogenase. All complexes include multiple copies of three components: an α-ketoacid dehydrogenase/decarboxylase, a dihydrolipoyl acyltransferase, and a dihydrolipoyl dehydrogenase. The mitochondrial pyruvate dehydrogenase complex additionally includes intrinsic regulatory protein-kinase and -phosphatase enzymes. The acyltransferases form the intricate geometric core structures of the complexes. Substrate channeling plus active-site coupling combine to greatly enhance the catalytic efficiency of these complexes. These α-ketoacid dehydrogenase complexes occupy key positions in intermediary metabolism, and a basic understanding of their properties is critical to genetic and metabolic engineering. The current status of knowledge of the biochemical, regulatory, structural, genomic, and evolutionary aspects of these fascinating multienzyme complexes are reviewed.
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