医学
免疫组织化学
黑色素瘤
内科学
淋巴
肿瘤科
转移
血管内皮生长因子
临床意义
癌症
血管内皮生长因子受体
病理
癌症研究
作者
Roger Mouawad,Jean‐Philippe Spano,Éva Compérat,Frédérique Capron,David Khayat
标识
DOI:10.1016/j.ejca.2008.12.015
摘要
Purpose The presence of metastases in regional lymph nodes is a strong indicator of poor patient survival in many types of cancer. It has recently been shown that vascular endothelial growth factor-C (VEGF-C), and its receptor VEGFR-3, may play a pivotal role in the promotion of metastasis to regional lymph nodes. This study was designed to detect and evaluate whether the expression of VEGFR-3 or its soluble form plays a role in metastatic malignant melanoma and to determine the relationship with clinicopathological parameters and patients outcome. Experimental design VEGFR-3 expression on melanoma tumour was evaluated by immunohistochemical study. Using a sensitive enzyme-linked immunosorbent assay, sVEGFR-3 was measured in sera of 60 metastatic melanoma patients in comparison with 30 healthy controls. Results Immunohistochemical study demonstrated a high expression of VEGFR-3 in melanoma cells. Median level of pre-treatment sVEGFR-3 was significantly higher (p = 0.00001) in melanoma patients as compared to healthy donors. No association was noted between VEGFR-3 in situ or in sera and gender, age or LDH level. Median serum VEGFR-3 levels were significantly higher in patients with high tumour burden as compared to those with low tumour burden (p = 0.013) as well as in non-responding patients (n = 33) as compared to responding ones (n = 27). Finally, low level of VEGFR-3 was also related positively to disease free survival (X2 = 3.85, p = 0.022). Conclusion These results suggest that the expression and high pre-treatment sVEGFR-3 level are significantly correlated to poorer prognosis, and may be promising targets for new therapeutic strategies in melanoma disease.
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