Effectiveness of live attenuated influenza vaccine and inactivated influenza vaccine in children 2–17 years of age in 2013–2014 in the United States

三价流感疫苗 病毒学 甲型流感病毒 免疫学 血凝试验 免疫原性 季节性流感 儿科 正粘病毒科 流感季节
作者
Hervé Caspard,Manjusha Gaglani,Lydia Clipper,Edward A. Belongia,Huong Q. McLean,Marie R. Griffin,H. Keipp Talbot,Katherine A. Poehling,Timothy R. Peters,Naomi Veney,Christopher S. Ambrose
出处
期刊:Vaccine [Elsevier BV]
卷期号:34 (1): 77-82 被引量:64
标识
DOI:10.1016/j.vaccine.2015.11.010
摘要

A postmarketing observational study was initiated to evaluate quadrivalent live attenuated influenza vaccine (LAIV) effectiveness in children aged 2-17 years in the United States.Children and adolescents aged 2-17 years seeking outpatient care for febrile acute respiratory illness <5 days duration were enrolled at 4 geographically diverse sites during the 2013-2014 influenza season. Nasal swabs were tested for influenza using reverse transcription polymerase chain reaction. Vaccination status was documented from medical records or immunization registries. Children who received ≥1 dose of influenza vaccine ≥14 days before study visit were considered vaccinated. Vaccine effectiveness (VE) was estimated as 100×(1-adjusted odds ratio), where the odds of interest are the odds of vaccine exposure among influenza cases and test-negative controls.In total, 1033 children and adolescents were included in the analysis. Influenza was detected in 14% (145/1033) of all children, with 74% (108/145) of the influenza cases due to A/H1N1pdm09 strains, 21% (31) to influenza B, and 4% (6) to influenza H3N2. LAIV did not show significant effectiveness against A/H1N1pdm09 (VE 13% [95% CI: -55 to 51]) but was effective against B/Yamagata strains (82% [95% CI: 12-96]). Inactivated influenza vaccine was effective against A/H1N1pdm09 (74% [95% CI: 50-86]) and B/Yamagata (70% [95% CI: 18-89]).LAIV provided significant protection against B/Yamagata influenza but not against A/H1N1pdm09 in children aged 2-17 years in 2013-2014, resulting in a proposed change of the 2015-2016 formulation with a new and more heat-stable A/H1N1pdm09 LAIV strain.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
秋天里的水完成签到,获得积分10
3秒前
wxy完成签到,获得积分10
4秒前
5秒前
香蕉觅云应助儒雅南风采纳,获得10
7秒前
郭小宝发布了新的文献求助10
11秒前
情怀应助幸福大白采纳,获得10
11秒前
齐天大圣应助幸福大白采纳,获得30
12秒前
孙燕应助幸福大白采纳,获得30
12秒前
英姑应助幸福大白采纳,获得30
12秒前
12秒前
Hashub完成签到,获得积分20
12秒前
14秒前
xueyu发布了新的文献求助10
16秒前
wonder123发布了新的文献求助10
17秒前
科研通AI2S应助张雯思采纳,获得10
18秒前
18秒前
小二郎应助张雯思采纳,获得10
18秒前
情怀应助张雯思采纳,获得10
18秒前
18秒前
科研通AI2S应助张雯思采纳,获得10
18秒前
今后应助张雯思采纳,获得10
18秒前
在水一方应助张雯思采纳,获得10
18秒前
Jasper应助张雯思采纳,获得10
18秒前
41应助张雯思采纳,获得10
18秒前
18秒前
新xin完成签到,获得积分10
19秒前
儒雅南风发布了新的文献求助10
19秒前
xxddw发布了新的文献求助10
19秒前
33发布了新的文献求助30
19秒前
20秒前
20秒前
Rondab应助科研小白采纳,获得10
21秒前
22秒前
wonder123完成签到,获得积分10
22秒前
量子星尘发布了新的文献求助10
24秒前
幸福的乾发布了新的文献求助10
24秒前
xyj6486发布了新的文献求助10
24秒前
25秒前
小晓发布了新的文献求助10
27秒前
Owen应助伏坎采纳,获得10
30秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174