化学
立体化学
晶体结构
钴
配体(生物化学)
氢键
分子内力
吡啶
八面体分子几何学
苯甲酸
细胞毒性
结晶学
药物化学
受体
体外
分子
生物化学
无机化学
有机化学
作者
Huijuan Jia,Mengyuan Niu,Rui Sun,Ai Wang,Yanbo Wu,Liping Lü,Mei Zhu,Sisi Feng,Caixia Yuan
标识
DOI:10.1016/j.molstruc.2022.133486
摘要
Cobalt complexes had exhibited the potential anti-diabetes abilities, but the mechanism is not so clear now. In this work, we synthesized and characterized a new cobalt(II) complex [Co(L)2Cl2]·1.5CH3OH·H2O (L=4-{[3-(pyridine-2-yl)-1H-pyrazol-1-yl]methyl}-benzoic acid). The crystal structure determination shows that the complex crystallizes in the triclinic system with P1¯ space group, where Co(II) center of the complex resides in a distorted octahedron with four N atoms from two pyridine-pyrazole ligands and two Cl− anions in a cis-configuration. The structure cohesion is ensured by intermolecular hydrogen bonds and intramolecular π···π stack interactions. Such a cobalt(II) complex shows moderate inhibition activity (IC50 = 35.6 µM) against T-cell protein tyrosine phosphatase (TCPTP), a potential target for therapy of diabetes. We speculate that the anti-diabetes ability of the cobalt complex may play its role by inhibiting the activity of TCPTP. Moreover, the MTT assays reveal that the complex exhibits relatively low cytotoxicity to cancer cell lines (MCF7, HepG2, and SW480) and the normal cell line (HL-7702).
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