化学
三氟甲基
区域选择性
试剂
催化作用
基质(水族馆)
有机化学
组合化学
组分(热力学)
作者
Lin Tang,Fang Yang,Shuai Zhang,Ge Lv,Qiuju Zhou,Lingyun Zheng
标识
DOI:10.1021/acs.joc.2c00477
摘要
The first Fe-catalyzed three-component radical trifluoromethyl-alkenylation of alkenes with 2-amino-1,4-naphthoquinones and CF3SO2Na is reported. The developed reaction enables the highly regioselective preparation of a variety of valuable CF3-substituted 1,4-naphthoquinones in acceptable yields. In the light of the catalytic system, alkynes smoothly afford the corresponding three- or four-component trifluoromethyl-alkenylation products. This protocol features use of easily available and inexpensive reagents, broad substrate scope, and simple reaction conditions.
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