2-Propanol is a common solvent in academic and industrial research laboratories, yet awareness around its classification as a Group B peroxide-forming solvent is lacking. Because of this deficiency, there have been several reports of explosions occurring during the distillation of 2-propanol that have resulted in injury to researchers. This Perspective discusses the historical literature around 2-propanol as a peroxide former and the potential for quality and safety hazard issues that come from trace peroxides in the solvent. Furthermore, the likelihood of peroxide formation in laboratory samples of 2-propanol is discussed with emphasis on the type of storage conditions.