医学
认知
神经保护
2型糖尿病
神经科学
执行功能障碍
糖尿病
2型糖尿病
生物信息学
重症监护医学
精神科
心理学
内科学
神经心理学
生物
内分泌学
作者
Ailin Luo,Zheng Xie,Yue Wang,Xuan Wang,Shan Li,Jing Yan,Gaofeng Zhan,Zhiqiang Zhou,Yilin Zhao,Shiyong Li
标识
DOI:10.1016/j.neubiorev.2022.104642
摘要
Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on personal health and put an enormous burden on the healthcare system, and increasing attention has been paid to T2D-associated cognitive dysfunction (TDACD). TDACD is characterized by cognitive dysfunction, delayed executive ability, and impeded information-processing speed. Brain imaging data suggest that extensive brain regions are affected in patients with T2D. Based on current findings, a wide spectrum of non-specific neurodegenerative mechanisms that partially overlap with the mechanisms of neurodegenerative diseases is hypothesized to be associated with TDACD. However, it remains unclear whether TDACD is a consequence of T2D or a complication that co-occurs with T2D. Theoretically, anti-diabetes methods are promising neuromodulatory approaches to reduce brain injury in patients with T2D. In this review, we summarize potential mechanisms underlying TDACD and promising neurotropic effects of anti-diabetes methods and some neuroprotective natural compounds. Constructing screening or diagnostic tools and developing targeted treatment and preventive strategies would be expected to reduce the burden of TDACD.
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