Development of lab-on-chip biosensor for the detection of toxic heavy metals: A review

Recently, a decrease in water availability and quality has been raised due to rapid industrialization, unsustainable agricultural activities and anthropogenic activities. Heavy metals are considered significant pollutants in the water environment, cause environmental hazards and health effects to humans. For monitoring water contaminants utilized different conventional techniques. Still, they have some drawbacks, such as cost expensive, ecological issues, and processing time, requiring technicians and researchers to operate them effectively. Biosensors have become reasonable devices for screening and identifying environmental contaminants because of their different benefits contrasted with other detecting techniques. This review summarizes the toxic effect of heavy metal and their source, occurrence. A detailed discussion is provided on the heavy metal recognition materials for detecting heavy metals in wastewater. Lab on chip (LOC) is an emerging micro-electrical mechanical system (MEMS) device that intakes liquid and makes it move through the micro-channels, to accomplish fast, cost-effective and profoundly sensitive analysis with significant yield. LOC also provided a discussion on numerous laboratory functions on a single platform. This article attempts to discuss the detection of heavy metals using lab on a chip by suitable recognition materials. Further, the design and fabrication mechanism and their recognition abilities of LOC were also reviewed. The review mainly focuses on the application of LOC biosensors, pros, and cons, and suggests a roadmap towards future development to enhance the practical use in pollutant monitoring.