Body Mass Index and PNPLA3 Genetic Variant Modify the Association of Alcohol Consumption With Liver Fat Content

We have read the recent article by De Vincentis et al1 with interest. The authors concluded that integration of genetics with clinical fibrosis scores refines individual risk and prediction for severe liver diseases, particularly in individuals at risk for nonalcoholic fatty liver disease. Although heavy alcohol consumption is an established risk factor for fatty liver disease,2 the association of low-to-moderate alcohol intake with nonalcoholic fatty liver disease remains controversial. To this end, we assessed the association between alcohol consumption and liver fat content.