New compounds from Sarcophyton glaucom-derived Penicillium sp.

Further investigation of the residual bioactive compounds produced by the soft coral Sarcophyton glaucom-derived Penicillium sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A (1), 9-methoxy-penicyrone B (2), 3-hydroxy-2,2,4-trimethyl-pentyl ester (3), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester (4), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate (5). Additional six known compounds were isolated: penicyrones A-B (6, 7), 4-(2-hydroxy-3-butynoxy)benzoic acid (8), cyclopenol (9), aspermytin A (10), and aurantiomide A (11). Structures of the new compounds (1-5) were identified by 1D (1H & 13C) and 2 D (1H-1H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.