自身免疫
免疫学
哮喘
自身抗体
医学
疾病
过敏
免疫系统
抗体
病理
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2022-01-01
卷期号:: 261-289
标识
DOI:10.1016/b978-0-323-85415-3.00013-1
摘要
The last decade has witnessed a growing interest in autoinflammation, which is related to an increase in knowledge about the immunopathogenesis of a broad spectrum of diseases, not only of immunological but also of allergic/inflammatory nature, such as asthma. Contrary to the belief that asthma and autoimmune diseases have little to share, a growing body of research supports autoimmune mechanisms underpinning disease severity in a subset of asthmatics, particularly severe asthmatics. Existing evidence suggests a plausible theory of breach of tolerance in asthma patients. The presence of autoantibodies as a hallmark of autoinflammation and the development of autoimmunity (clinical manifestations caused by autoantibody-mediated inflammation) in asthma are parts of a spectrum of immunological phenomena, following the pattern that innate and adaptive immune responses constitute the immunological continuum. Besides, cutting-edge molecular techniques have revealed common genetic variants between asthma and the wide spectrum of autoimmune diseases.
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