Drawing on family systems framework, this study investigated the reciprocal prospective associations between marital relationship quality, parent-adolescent closeness and conflict, and adolescent depressive symptoms among families in Taiwan.The family systems theory posits reciprocity between family subsystems. However, the direction of influences between marital relationship quality, parent-adolescent relationship quality and adolescent well-being may be more unidirectional in Chinese societies due to hierarchical family values.Data were from a longitudinal survey of 2,292 parent-youth dyads in the Taiwan Youth Project. Cross-lagged path models were used to test the bidirectional associations between marital relationship quality, parent-adolescent closeness and conflict, and adolescent depressive symptoms from ages 12 to 18.Our primary hypothesis that marital relationship quality predicts parent-adolescent relationship quality, which then predicts adolescent depressive symptoms in a unidirectional manner was partially substantiated. Moreover, marital relationship quality directly predicted fewer depressive symptoms from middle to late adolescence and indirectly from early to late adolescence via parent-adolescent relationship quality in middle adolescence. We also found that child depressive symptoms predicted less parent-adolescent closeness, and more conflicts which predicted poorer marital relationship quality, particularly in early adolescence.Extending the family systems theory, findings suggest that marital relationship quality plays a dominant role in the health and well-being of Taiwanese families, especially as adolescents mature. Results highlight the importance of testing theories in families from diverse cultures.