羟甲唑啉
医学
鼻腔给药
鼻喷雾剂
皮质类固醇
鼻减充血剂
麻醉
安慰剂
盐酸盐
鼻塞
鼻子
药理学
内科学
外科
化学
有机化学
替代医学
受体
病理
肾上腺素能受体
作者
Cindy Lee P. Neighbors,C Fernandez Salvador,Bovey Z. Zhu,Macario Camacho,Paulus D. Tsai
出处
期刊:Journal of Laryngology and Otology
[Cambridge University Press]
日期:2021-10-27
卷期号:136 (1): 8-16
被引量:1
标识
DOI:10.1017/s0022215121003364
摘要
Abstract Objective This study aimed to summarise the evidence for efficacy of combination treatment of intranasal corticosteroid spray with oxymetazoline hydrochloride nasal spray for chronic rhinitis. Method Nine databases were systematically searched from study inception in September 2016 to 1 June 2020. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed. Results A total of 130 studies were screened, and 4 randomised controlled trials comprising 838 patients met inclusion criteria. The study found superior improvement of nasal congestion from onset of treatment to completion in intranasal corticosteroid spray and oxymetazoline hydrochloride groups compared with control groups. Intranasal corticosteroid spray and oxymetazoline hydrochloride use resulted in higher nasal volume (standard error of mean 1, 15.8 + 1.1 ml; p < .03) compared with either placebo (12.1 + 0.9 ml) or oxymetazoline hydrochloride (12.4 + 0.8 ml) alone ( p = 0.003). Conclusion Intranasal corticosteroid spray and oxymetazoline hydrochloride combination treatment may be superior in reducing rhinitis symptoms compared with either intranasal corticosteroid spray or oxymetazoline hydrochloride alone, without inducing rhinitis medicamentosa.
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