CD40
T细胞
克隆(Java方法)
CD8型
细胞毒性T细胞
生物
细胞生物学
分子生物学
B细胞
抗原提呈细胞
白细胞介素21
配体(生物化学)
受体
抗原
免疫系统
抗体
免疫学
体外
生物化学
基因
作者
David Cronin,R M Stack,F W Fitch
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1995-04-01
卷期号:154 (7): 3118-3127
被引量:98
标识
DOI:10.4049/jimmunol.154.7.3118
摘要
Interactions between CD4+ T cells and B cells are mediated by both soluble factors and cell surface molecules. The Ag-independent interaction between the CD40 ligand, expressed on activated T cells, and its CD40 receptor, expressed on B cells, enhances B cell proliferation in response to IL-4 stimulation. The expression of the CD40 ligand is induced on CD4+ T cells by stimulation with Ag-pulsed APC or mitogens. Here, we show that at least some IL-4-producing murine CD8+ T cell clones can be induced to express the CD40 ligand when stimulated with anti-CD3 mAb. Additionally, such activated CD8+ IL-4-producing clones potentiate the proliferative response of small resting B cells to IL-4 and induce Ig secretion by small resting B cells to IL-4 and IL-5. Proliferation of small resting B cells cultured with IL-4 in the presence of activated IL-4-producing CD8+ murine T cell clones appeared to be mediated by the expression of the CD40 ligand on the T cell because an anti-CD40 ligand mAb inhibited this proliferative response. A conventional murine CD8+ CTL clone, which did not produce IL-4 or express CD40 ligand upon activation, did not potentiate proliferation of small resting B cells exposed to IL-4. Thus, under some circumstances, CD8+ T cells that are able to express CD40 ligand may be able to provide B cell help.
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