血管生成
软骨
血管内皮生长因子
软骨细胞
骨关节炎
软骨内骨化
新生血管
血管内皮生长因子受体
血管内皮生长因子A
炎症
医学
血管内皮生长因子C
细胞生物学
免疫学
癌症研究
病理
生物
解剖
替代医学
作者
Mitsunobu Murata,Kazuo Yudoh,Kayo Masuko
标识
DOI:10.1016/j.joca.2007.09.003
摘要
Although adult human cartilage is physiologically avascular tissue, angiogenesis can be observed during the process of endochondral bone development. Inflammation in articular joints can also lead to neovascularization in cartilage. In such conditions, the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF), has been shown to play a key role, controlling not only angiogenesis but also chondrocyte metabolism. Here we review recent research findings concerning the potential role of VEGF in cartilage, focusing in particular on its possible involvement in the pathogenesis of osteoarthritis.
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