神经影像学
自闭症谱系障碍
内表型
神经科学
自闭症
心理学
神经功能成像
医学
精神科
认知
作者
Rajneesh Mahajan,Stewart H. Mostofsky
出处
期刊:CNS spectrums
[Cambridge University Press]
日期:2015-08-01
卷期号:20 (4): 412-426
被引量:40
标识
DOI:10.1017/s1092852915000371
摘要
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has a strong genetic basis, and is heterogeneous in its etiopathogenesis and clinical presentation. Neuroimaging studies, in concert with neuropathological and clinical research, have been instrumental in delineating trajectories of development in children with ASD. Structural neuroimaging has revealed ASD to be a disorder with general and regional brain enlargement, especially in the frontotemporal cortices, while functional neuroimaging studies have highlighted diminished connectivity, especially between frontal-posterior regions. The diverse and specific neuroimaging findings may represent potential neuroendophenotypes, and may offer opportunities to further understand the etiopathogenesis of ASD, predict treatment response, and lead to the development of new therapies.
科研通智能强力驱动
Strongly Powered by AbleSci AI