阿比坦
IC50型
结核分枝杆菌
立体化学
生物信息学
大戟
化学
萜类
内酯
生物化学
生物
传统医学
体外
肺结核
植物
医学
病理
基因
作者
Yun‐Long Wei,Chao Wang,Zhongbin Cheng,Xiangge Tian,Jing‐Ming Jia,Yonglei Cui,Lei Feng,Cheng‐Peng Sun,Baojing Zhang,Xiaochi Ma
标识
DOI:10.1021/acs.jnatprod.7b00595
摘要
Two heterodimeric diterpenoids (1 and 2) comprising abietane lactone and nor-rosane constituent units were isolated from Euphorbia ebracteolata roots. Compound 1 exhibited a moderate inhibitory effect on α-glucosidase (IC50 = 7.94 μM), with a Ki value of 10.8 μM. In silico molecular docking has been performed to investigate the inhibition mechanism. Compound 2 inhibited the acetyl transfer activity of Mycobacterium tuberculosis GlmU (IC50 = 41.85 μM), which is a novel tuberculosis treatment target.
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