Benefit of left atrial appendage electrical isolation for persistent and long-standing persistent atrial fibrillation: a systematic review and meta-analysis

医学 心房颤动 内科学 心脏病学 导管消融 置信区间 荟萃分析 相对风险 心耳 烧蚀 冲程(发动机) 窦性心律 机械工程 工程类
作者
Jorge Romero,Gregory F. Michaud,Ricardo Avendaño,David Briceño,Saurabh Kumar,Juan Carlos Díaz,Sanghamitra Mohanty,Chintan Trivedi,Carola Gianni,Domenico Della Rocca,Riccardo Proietti,Laura Perrotta,Stefano Bordignon,Julian K R Chun,Boris Schmidt,Mario J. García,Andrea Natale,Luigi Di Biase
出处
期刊:Europace [Oxford University Press]
卷期号:20 (8): 1268-1278 被引量:61
标识
DOI:10.1093/europace/eux372
摘要

The long-term outcomes of left atrial appendage electrical isolation (LAAEI) in patients with non-paroxysmal atrial fibrillation (AF) have corroborated the significant role of the LAA in this arrhythmia. We sought to investigate the incremental benefit of LAAEI in patients undergoing catheter ablation for persistent AF or long-standing persistent AF (LSPAF). A systematic review of Medline, Cochrane, and Embase for all the clinical studies in which assessment LAAEI in non-paroxysmal AF patients was performed. The benefit of LAAEI in patients with AF was analysed from seven studies that enrolled a total of 930 patients [mean age 63 ± 5 years; male: 69%]. All studies included patients with either persistent AF or LSPAF or the combination of them. The overall freedom from all-arrhythmia recurrence at 12 months of follow-up off antiarrhythmic medications in patients who underwent LAAEI was 75.5% vs. 43.9% in those in whom only standard ablation was performed [56% relative reduction and 31.6% absolute reduction; risk ratio (RR) 0.44, 95% confidence interval (95% CI) 0.31–0.64; P < 0.0001]. The rate of ischaemic stroke in the LAAEI group was 0.4% and in the control group 2.1% at 12 months follow-up (RR 0.40, 95% CI 0.12–1.30; P = 0.13). Acute complications rates were identical between groups [LAAEI 5.5%, control 5.5% (RR 0.99, 95% CI 0.46–2.16; P = 0.99)]. Left atrial appendage electrical isolation in addition to standard ablation appears to have a substantial incremental benefit to achieve freedom from ALL atrial arrhythmias in patients with persistent AF and LSPAF without increasing acute procedural complications and without raising the risk of ischaemic stroke.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
可爱的函函应助sl采纳,获得30
1秒前
CatC完成签到,获得积分10
1秒前
LIKO完成签到,获得积分10
1秒前
1秒前
1秒前
David发布了新的文献求助10
2秒前
2秒前
clock完成签到 ,获得积分10
2秒前
风中小懒虫完成签到,获得积分10
3秒前
cindy完成签到 ,获得积分10
4秒前
Tysonqu完成签到,获得积分10
4秒前
科研通AI2S应助Promise采纳,获得10
5秒前
6秒前
淡淡阁完成签到 ,获得积分10
6秒前
念念发布了新的文献求助10
6秒前
漂亮的秋天完成签到 ,获得积分10
8秒前
David完成签到,获得积分10
8秒前
Jason完成签到,获得积分10
8秒前
12秒前
13秒前
13秒前
YY完成签到,获得积分10
14秒前
调皮的凝旋完成签到,获得积分10
15秒前
15秒前
念念完成签到,获得积分20
16秒前
崔悦欣完成签到,获得积分10
18秒前
xiaosui完成签到 ,获得积分10
18秒前
夏初水莲洁完成签到,获得积分10
19秒前
Jasper应助小王采纳,获得10
19秒前
ZXH完成签到,获得积分10
20秒前
20秒前
Promise发布了新的文献求助10
20秒前
个性德天完成签到,获得积分10
21秒前
清颜完成签到 ,获得积分10
22秒前
大侦探皮卡丘完成签到,获得积分10
23秒前
pan完成签到,获得积分10
24秒前
24秒前
白石溪完成签到,获得积分10
26秒前
27秒前
27秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029