溶解循环
金黄色葡萄球菌
抗菌剂
微生物学
抗生素耐药性
赖氨酸
人类健康
生物
抗生素
噬菌体疗法
葡萄球菌感染
计算生物学
噬菌体
医学
细菌
病毒学
病毒
遗传学
基因
环境卫生
大肠杆菌
作者
Diana Gutiérrez,Lucía Fernández,Ana Rodrı́guez,Pilar Garcı́a
出处
期刊:MBio
[American Society for Microbiology]
日期:2018-03-07
卷期号:9 (1)
被引量:93
标识
DOI:10.1128/mbio.01923-17
摘要
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening microorganisms for global human health. The current strategies to reduce the impact of S. aureus include a restrictive control of worldwide antibiotic use, prophylactic measures to hinder contamination, and the search for novel antimicrobials to treat human and animal infections caused by this bacterium. The last strategy is currently the focus of considerable research. In this regard, phage lytic proteins (endolysins and virion-associated peptidoglycan hydrolases [VAPGHs]) have been proposed as suitable candidates. Indeed, these proteins display narrow-spectrum antimicrobial activity and a virtual lack of bacterial-resistance development. Additionally, the therapeutic use of phage lytic proteins in S. aureus animal infection models is yielding promising results, showing good efficacy without apparent side effects. Nonetheless, human clinical trials are still in progress, and data are not available yet. This minireview also analyzes the main obstacles for introducing phage lytic proteins as human therapeutics against S. aureus infections. Besides the common technological problems derived from large-scale production of therapeutic proteins, a major setback is the lack of a proper legal framework regulating their use. In that sense, the relevant health authorities should urgently have a timely discussion about these new antimicrobials. On the other hand, the research community should provide data to dispel any doubts regarding their efficacy and safety. Overall, the appropriate scientific data and regulatory framework will encourage pharmaceutical companies to invest in these promising antimicrobials.
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