Effect of Chaihu Shugan Powder on content of hippocampus neurotransmitter in depression rats

Objective To explore the effect of Chaihu Shugan Powder(CSP)on content of hippocampus neurotransmitter in depression rats.Methods Sixty SD rats were randomly divided into were blank group,model group,fluoxetine group, medium-dose and high-dose CSP group,12 cases in each group.Reserpine injection were intraperitoneal injected for continuous14days to establish model in all the groups except the blank group.After establishing,the fluoxetine group, medium-dose and high-dose CSP group were treated with 9mL/kg of fluoxetine,5g/kg and 10g/kg of CSP respectively.After the 0,4,7,10,14days of administration,the weight was recorded;after the 0,7,14days,the score of Open-Field was calculated;the content of 5-hydroxytryptamine(5-HT),noradrenaline(NE)and dopamine(DA)of monoamine neurotransmitter in hippocampus tissue was detected by ELISA.Results Compared with the model group,the weight, horizontal and vertical score,and content of 5-HT,NE and DA in the high-dose CSP group were obviously increased,with significant difference(P0.05or P0.01);horizontal score and the content of 5-HT and DA in the medium-dose CSP group were apparently increased,with significant difference(P0.05or P0.01).Conclusion CSP has a good effect on antidepression,which might be related with increasing the content of monoamine neurotransmitter in hippocampus tissue.