化学
激酶
细胞周期蛋白依赖激酶
癌症研究
细胞周期蛋白依赖激酶8
基因
生物化学
细胞周期
Notch信号通路
生物
作者
Jianyu Xu,Hongyun Qi,Zhen Wang,Ling Wang,Barbara Steurer,Xin Cai,Jinxin Liu,Alex Aliper,Man Zhang,Feng Ren,Alex Zhavoronkov,Xiao Ding
标识
DOI：10.1021/acs.jmedchem.4c00248
摘要
The mediator kinases CDK8 and CDK19 control the dynamic transcription of selected genes in response to various signals and have been shown to be hijacked to sustain hyperproliferation by various solid and liquid tumors. CDK8/19 is emerging as a promising anticancer therapeutic target. Here, we report the discovery of compound
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