液体活检
循环肿瘤细胞
生物传感器
癌症生物标志物
细胞外小泡
癌症检测
癌症
纳米技术
活检
适体
计算生物学
医学
材料科学
病理
生物
分子生物学
内科学
细胞生物学
转移
作者
Nana Lyu,Amin Hassanzadeh‐Barforoushi,Laura M. Rey Gomez,Wei Zhang,Yuling Wang
标识
DOI:10.1186/s40580-024-00428-3
摘要
Abstract Liquid biopsy has emerged as a promising non-invasive strategy for cancer diagnosis, enabling the detection of various circulating biomarkers, including circulating tumor cells (CTCs), circulating tumor nucleic acids (ctNAs), circulating tumor-derived small extracellular vesicles (sEVs), and circulating proteins. Surface-enhanced Raman scattering (SERS) biosensors have revolutionized liquid biopsy by offering sensitive and specific detection methodologies for these biomarkers. This review comprehensively examines the application of SERS-based biosensors for identification and analysis of various circulating biomarkers including CTCs, ctNAs, sEVs and proteins in liquid biopsy for cancer diagnosis. The discussion encompasses a diverse range of SERS biosensor platforms, including label-free SERS assay, magnetic bead-based SERS assay, microfluidic device-based SERS system, and paper-based SERS assay, each demonstrating unique capabilities in enhancing the sensitivity and specificity for detection of liquid biopsy cancer biomarkers. This review critically assesses the strengths, limitations, and future directions of SERS biosensors in liquid biopsy for cancer diagnosis.
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