百里香醌
细菌纤维素
化学
渗透
纤维素
环糊精
膜
色谱法
羟丙基纤维素
甲基纤维素
核化学
有机化学
生物化学
聚合物
抗氧化剂
作者
Sam Swingler,Abhishek Gupta,Hazel Gibson,Marek Kowalczuk,Grażyna Adamus,Wayne Heaselgrave,Iza Radecka
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2022-12-15
卷期号:14 (12): 2816-2816
被引量:3
标识
DOI:10.3390/pharmaceutics14122816
摘要
The need for more advantageous and pharmaceutically active wound dressings is a pressing matter in the area of wound management. In this study, we explore the possibility of incorporating thymoquinone within bacterial cellulose, utilising cyclodextrins as a novel method of solubilising hydrophobic compounds. The thymoquinone was not soluble in water, so was incorporated within hydroxypropyl-β-cyclodextrin before use. Thymoquinone: hydroxypropyl-β-cyclodextrin inclusion complex produced was found to be soluble in water up to 7% (w/v) and was stable with no crystal formation for at least 7 days with the ability to be loaded within the bacterial cellulose matrix. The inclusion complex was found to be thermally stable up to 280 °C which is far greater than the production temperature of 80 °C and was stable in phosphate-buffered saline and extraction solvents in permeation and dose experiments. The adhesion properties of the Thymoquinone: hydroxypropyl-β-cyclodextrin loaded bacterial cellulose dressings were tested and found to be 2.09 N. Permeation studies on skin mimicking membrane Strat-M showed a total permeated amount (0–24 h) of 538.8 µg cm−2 and average flux after a 2 h lag of 22.4 µg h−1 cm−2. To the best of our knowledge, the methods outlined in this study are the first instance of loading bacterial cellulose with thymoquinone inclusion complex with the aim of producing a pharmaceutically active wound dressing.
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