表观遗传学
癌症
癌症表观遗传学
癌变
组蛋白
癌细胞
后生
癌症研究
细胞生物学
计算生物学
生物
遗传学
组蛋白甲基转移酶
基因表达
DNA甲基化
DNA
基因
作者
Xinyu Lv,Yingying Lv,Xiaofeng Dai
出处
期刊:Expert Reviews in Molecular Medicine
[Cambridge University Press]
日期:2023-01-01
卷期号:25
被引量:30
摘要
Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.
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