Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials

诱导多能干细胞 重编程 医学 老化 预期寿命 干细胞 再生医学 人口 体细胞 神经科学 胚胎干细胞 生物 生物信息学 遗传学 内科学 环境卫生 基因 细胞
作者
Filipa Esteves,David V.C. Brito,Ana Teresa Rajado,Nádia Silva,Joana Apolónio,Vânia Palma Roberto,Inês M. Araújo,Clévio Nóbrega,Pedro Castelo‐Branco,José Bragança,Raquel P. Andrade,Sofia M. Calado,Maria Leonor Faleiro,Carlos A. Matos,Nuno Marques,Ana Marreiros,Hipólito Nzwalo,Sandra Pais,Isabel Palmeirim,Sónia Simão,Natércia Joaquim,Rui Miranda,António Pêgas,D. Raposo,Ana Paula Sardo
出处
期刊:Mechanisms of Ageing and Development [Elsevier]
卷期号:214: 111854-111854 被引量:7
标识
DOI:10.1016/j.mad.2023.111854
摘要

The unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases, and to expand health span. The establishment of induced pluripotent stem cells (iPSCs) by reprogramming human somatic cells has revolutionised the modelling and understanding of human diseases. iPSCs have a major advantage relative to other human pluripotent stem cells as their obtention does not require the destruction of embryos like embryonic stem cells do, and do not have a limited proliferation or differentiation potential as adult stem cells. Besides, iPSCs can be generated from somatic cells from healthy individuals or patients, which makes iPSC technology a promising approach to model and decipher the mechanisms underlying the ageing process and age-associated diseases, study drug effects, and develop new therapeutic approaches. This review discusses the advances made in the last decade using iPSC technology to study the most common age-associated diseases, including age-related macular degeneration (AMD), neurodegenerative and cardiovascular diseases, brain stroke, cancer, diabetes, and osteoarthritis.
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