自愈水凝胶
类有机物
诱导多能干细胞
纳米技术
细胞外基质
再生医学
组织工程
生物相容性
材料科学
干细胞
生物医学工程
细胞生物学
生物
胚胎干细胞
工程类
生物化学
基因
高分子化学
冶金
作者
Yihan Li,Qimanguli Saiding,Zhen Wang,Wenguo Cui
标识
DOI:10.1016/j.pmatsci.2023.101216
摘要
Organoids, intricate three-dimensional tissue assemblies derived from either pluripotent or adult stem cells cultured under laboratory conditions, emerge as a captivating model and innovative tool for modern medical research. Biomimetic substrates aim to mirror the in vivo microenvironment, proving crucial for the successful cultivation of organoids. Biomimetic hydrogels, meticulously engineered to emulate the native extracellular matrix milieu, now serve as robust analogs of the in vivo niche pivotal for steering stem cell destiny. The present review delves into the evolution and advancements in hydrogel biomaterials tailored for organoid culture. We explore the intrinsic properties of hydrogels that render them suitable for this application, from their biocompatibility to tunable mechanical properties. Special attention is given to the recent innovations in hydrogel design, aiming to achieve meticulous spatiotemporal control over embedded biochemical cues and their consequential impact on organoid formation, differentiation, and maturation. Furthermore, challenges and potential solutions in scaling and commercial application of these hydrogel systems for therapeutic use are discussed. Conclusively, this review highlights the symbiotic relationship between organoids and hydrogels, elucidating the potential and limitations of this partnership in advancing medical research.
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