Comparison among presepsin, procalcitonin, and C-reactive protein in predicting blood culture positivity and pathogen in sepsis patients

降钙素原 败血症 内科学 血培养 胃肠病学 医学 接收机工作特性 C反应蛋白 逻辑回归 菌血症 曲线下面积 病菌 免疫学 微生物学 生物 抗生素 炎症
作者
Hongli Xiao,Hanyu Zhang,Guoxing Wang,Yan Wang,Zhimin Tan,Xuelian Sun,Jie Zhou,Meili Duan,Deyuan Zhi,Chenchen Hang,Guoqiang Zhang,Yan Li,Caijun Wu,Haiyan Zhang,Miaorong Xie,Chunsheng Li
出处
期刊:Shock [Lippincott Williams & Wilkins]
被引量:6
标识
DOI:10.1097/shk.0000000000002243
摘要

Abstract Background Sepsis is caused by the invasion of the bloodstream by microorganisms from local sites of infection, leading to high mortality. This study aimed to compare the predictive ability of the biomarkers presepsin, procalcitonin (PCT) and C-reactive protein (CRP) for bacteraemia. Methods In this retrospective, multicentre study, a dataset of patients with sepsis who were prospectively enrolled between November 2017 and June 2021 was analysed. The performances of the biomarkers for predicting positive blood cultures and infection with specific pathogens were assessed by the areas under the receiver operating characteristic curves (AUCs). The independent effects of the pathogen and foci of infection on presepsin and PCT levels were assessed by linear logistic regression models. Results A total of 577 patients with 170 (29.5%) positive blood cultures were enrolled. The AUC achieved using PCT levels (0.856) was significantly higher than that achieved using presepsin (0.786, p = 0.0200) and CRP (0.550, p < 0.0001) levels in predicting bacteraemia. The combined analysis of PCT and presepsin levels led to a significantly higher AUC than the analysis of PCT levels alone for predicting blood culture positivity (0.877 vs. 0.856, p = 0.0344) and gram-negative bacteraemia (0.900 vs. 0.875, p = 0.0216). In a linear regression model, the elevated concentrations of presepsin and PCT were both independently related to E. coli , Klebsiella spp., Pseudomonas spp., and Streptococcus spp. infections and Sequential Organ Failure Assessment (SOFA) score. Presepsin levels were also associated with Acinetobacter spp. and abdominal infection, and PCT levels were positively associated with other Enterobacteriaceae and negatively associated with respiratory infection. Combined analysis of presepsin and PCT levels provided a high sensitivity and specificity in identifying Escherichia coli or Klebsiella spp infection. Conclusions Presepsin and PCT were promising markers for predicting bacteraemia and common pathogens at the time of sepsis onset with a synergistic effect.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
研友_892kOL发布了新的文献求助10
刚刚
1秒前
共享精神应助积极盼山采纳,获得10
2秒前
寒冷的奇异果完成签到,获得积分10
2秒前
一颗小洋葱完成签到 ,获得积分10
2秒前
研友_LMBAXn完成签到,获得积分10
5秒前
Aurora.H完成签到,获得积分10
5秒前
1122完成签到 ,获得积分10
6秒前
亚高山暗针叶林完成签到 ,获得积分10
6秒前
一米八完成签到 ,获得积分10
7秒前
7秒前
年少丶完成签到,获得积分10
7秒前
大美美完成签到,获得积分10
8秒前
nicheng完成签到 ,获得积分0
9秒前
11秒前
大吴克发布了新的文献求助10
12秒前
xdd发布了新的文献求助100
12秒前
fffff完成签到,获得积分10
13秒前
大巧若拙完成签到,获得积分10
14秒前
吕佳完成签到 ,获得积分10
15秒前
ooo发布了新的文献求助10
15秒前
delilicate完成签到 ,获得积分10
16秒前
这课题真顺利完成签到,获得积分10
16秒前
小城故事完成签到,获得积分10
17秒前
17秒前
李小明完成签到,获得积分10
19秒前
沉默傲芙完成签到,获得积分10
19秒前
20秒前
顾矜应助ooo采纳,获得10
21秒前
那时年少完成签到,获得积分10
24秒前
震动的沉鱼完成签到 ,获得积分10
24秒前
克偃统统完成签到 ,获得积分10
25秒前
八点必起完成签到,获得积分10
26秒前
flymove完成签到,获得积分10
26秒前
林登万完成签到,获得积分10
27秒前
Wang发布了新的文献求助10
31秒前
晨青完成签到,获得积分10
31秒前
笨笨青筠完成签到 ,获得积分10
32秒前
caicai完成签到,获得积分10
32秒前
SC完成签到,获得积分10
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513400
关于积分的说明 11167585
捐赠科研通 3248853
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875131
科研通“疑难数据库(出版商)”最低求助积分说明 804664