Macrostructural Cerebellar Neuroplasticity Correlates With Motor Recovery After Stroke

小脑 神经可塑性 心理学 辅助电机区 运动皮层 物理医学与康复 冲程(发动机) 基于体素的形态计量学 神经科学 磁共振成像 功能磁共振成像 医学 白质 放射科 机械工程 刺激 工程类
作者
Takashi Hanakawa,Fujiko Hotta,Tatsuhiro Nakamura,Keiichiro Shindo,Naoko Ushiba,Masaki Hirosawa,Yutaka Yamazaki,Yoshinao Moriyama,Syota Takagi,Katsuhiro Mizuno,Meigen Liu
出处
期刊:Neurorehabilitation and Neural Repair [SAGE Publishing]
卷期号:37 (11-12): 775-785 被引量:8
标识
DOI:10.1177/15459683231207356
摘要

Motor recovery varies across post-stroke individuals, some of whom require a better rehabilitation strategy. We hypothesized that macrostructural neuroplasticity of the motor control network including the cerebellum might underlie individual differences in motor recovery. Objectives. To gain insight into the macrostructural neuroplasticity after stroke, we examined 52 post-stroke individuals using both the Fugl-Meyer assessment and structural magnetic resonance imaging.We performed voxel-based lesion symptom mapping and cross-sectional voxel-based morphometry to correlate the motor scores with the lesion location and the gray matter volume (GMV), respectively. Longitudinal data were available at ~8 and/or 15 weeks after admission from 43 individuals with supratentorial lesions. We performed a longitudinal VBM analysis followed by a multiple regression analysis to correlate between the changes of the motor assessment scores and those of GMV overtime.We found a cross-sectional correlation of residual motor functioning with GMV in the ipsilesional cerebellum and contralesional parietal cortex. Longitudinally, we found increases in GMV in the ipsilesional supplementary motor area, and the ipsilesional superior and inferior cerebellar zones, along with a GMV decrease in the ipsilesional thalamus. The motor recovery was correlated with the GMV changes in the superior and inferior cerebellar zones. The regaining of upper-limb motor functioning was correlated with the GMV changes of both superior and inferior cerebellum while that of lower-limb motor functioning with the GMV increase of the inferior cerebellum only.The present findings support the hypothesis that macrostructural cerebellar neuroplasticity is correlated with individual differences in motor recovery after stroke.
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