免疫原性
化学
蛋白质化学
小分子
蛋白质工程
纳米技术
蛋白质稳定性
计算生物学
组合化学
生物化学
生物
材料科学
免疫系统
酶
免疫学
作者
Linqi Cheng,Yixian Wang,Yiming Guo,Sophie S. Zhang,Han Xiao
标识
DOI:10.1016/j.chembiol.2023.09.004
摘要
Recent years have seen a remarkable growth in the field of protein-based medical treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low affinity, potential immunogenicity, low stability, and challenges to modify these proteins. To overcome these obstacles, proximity-induced chemistry has emerged as a next-generation strategy for advancing protein therapeutics. This method allows site-specific modification of proteins with therapeutic agents, improving their effectiveness without extensive engineering. In addition, this innovative approach enables spatial control of the reaction based on proximity, facilitating the formation of irreversible covalent bonds between therapeutic proteins and their targets. This capability becomes particularly valuable in addressing challenges such as the low affinity frequently encountered between therapeutic proteins and their targets, as well as the limited availability of small molecules for specific protein targets. As a result, proximity-induced chemistry is reshaping the field of protein drug preparation and propelling the revolution in novel protein therapeutics.
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