Targeting survivin for cancer therapy: Strategies, small molecule inhibitors and vaccine based therapeutics in development

生存素 癌症研究 细胞凋亡 凋亡抑制因子 化疗 癌症 医学 生物 程序性细胞死亡 内科学 生物化学
作者
Sree Karani Kondapuram,Hema Kasthuri Ramachandran,Hemant Arya,Mohane Selvaraj Coumar
出处
期刊:Life Sciences [Elsevier]
卷期号:335: 122260-122260 被引量:7
标识
DOI:10.1016/j.lfs.2023.122260
摘要

Survivin is a member of the family of inhibitors of apoptosis proteins (IAPs). It is involved in the normal mitotic process and acts as an anti-apoptotic molecule. While terminally differentiated normal tissues lack survivin, several human malignancies have significant protein levels. Resistance to chemotherapy and radiation in tumor cells is associated with survivin expression. Decreased tumor development, apoptosis, and increased sensitivity to chemotherapy and radiation are all effects of downregulating survivin expression or activity. As a prospective cancer treatment, small molecules targeting the transcription and translation of survivin and molecules that can directly bind with the survivin are being explored both in pre-clinical and clinics. Pre-clinical investigations have found and demonstrated the effectiveness of several small-molecule survivin inhibitors. Unfortunately, these inhibitors have also been shown to have off-target effects, which could limit their clinical utility. In addition to small molecules, several survivin peptide vaccines are currently under development. These vaccines are designed to elicit a cytotoxic T-cell response against survivin, which could lead to the destruction of tumor cells expressing survivin. Some survivin-based vaccines are advancing through Phase II clinical studies. Overall, survivin is a promising cancer drug target. However, challenges still need to be addressed before the survivin targeted therapies can be widely used in the clinics.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
liuke发布了新的文献求助10
1秒前
2秒前
棋棋233完成签到,获得积分10
4秒前
5秒前
英姑应助夏冰雹采纳,获得10
6秒前
隐形曼青应助catherine采纳,获得10
6秒前
善学以致用应助马焕采纳,获得10
8秒前
junjun发布了新的文献求助30
10秒前
汉堡包应助学术工人采纳,获得10
10秒前
瑞瑞发布了新的文献求助10
11秒前
大模型应助joni采纳,获得10
13秒前
14秒前
14秒前
Endless完成签到,获得积分10
15秒前
扶苏在上完成签到,获得积分10
15秒前
16秒前
哈哈应助markerfxq采纳,获得10
18秒前
xx发布了新的文献求助10
19秒前
19秒前
夏冰雹发布了新的文献求助10
20秒前
Krapanda发布了新的文献求助10
20秒前
Agamemnon发布了新的文献求助30
21秒前
24秒前
网再快点发布了新的文献求助10
26秒前
27秒前
活泼又晴完成签到,获得积分10
27秒前
夏冰雹完成签到,获得积分10
27秒前
xdd关闭了xdd文献求助
29秒前
小妤丸子发布了新的文献求助10
29秒前
xhy发布了新的文献求助10
29秒前
30秒前
joni发布了新的文献求助30
30秒前
酷波er应助风中的天菱采纳,获得10
31秒前
Wang发布了新的文献求助10
33秒前
33秒前
Triumph发布了新的文献求助10
33秒前
34秒前
ziyewutong应助chen采纳,获得150
35秒前
AbeleChuang发布了新的文献求助10
38秒前
深情安青应助Wang采纳,获得10
39秒前
高分求助中
Sustainability in Tides Chemistry 2000
The ACS Guide to Scholarly Communication 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Ожившие листья и блуждающие цветы. Практическое руководство по содержанию богомолов [Alive leaves and wandering flowers. A practical guide for keeping praying mantises] 500
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3080354
求助须知:如何正确求助?哪些是违规求助? 2733117
关于积分的说明 7526931
捐赠科研通 2382128
什么是DOI,文献DOI怎么找? 1263212
科研通“疑难数据库(出版商)”最低求助积分说明 612225
版权声明 597498