锡尔图因
氧化应激
SIRT3
SIRT6型
2型糖尿病
胰岛素抵抗
活性氧
机制(生物学)
西妥因1
医学
糖尿病
SIRT2
氧化磷酸化
2型糖尿病
生物
药理学
生物信息学
内分泌学
细胞生物学
生物化学
下调和上调
乙酰化
哲学
认识论
基因
作者
Jiawen Chen,Qi Wang,Ruiyan Li,Zhe Li,Qizhou Jiang,Fangrong Yan,Junmei Ye
出处
期刊:Life Sciences
[Elsevier BV]
日期:2023-10-17
卷期号:333: 122187-122187
被引量:15
标识
DOI:10.1016/j.lfs.2023.122187
摘要
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and impaired glucose homeostasis. Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) production and antioxidant defense systems, plays a significant role in the development and progression of T2DM. The sirtuin family, particularly Sirt1, Sirt3, and Sirt6, have emerged as key regulators of oxidative stress in various cellular processes. This review aims to explore the role of the sirtuin family in oxidative stress during the progression of T2DM and their potential as therapeutic targets. We discussed the mechanisms through which sirtuins modulate oxidative stress, their impact on insulin sensitivity, and beta-cell function involved in T2DM. Furthermore, we highlight drugs targeting sirtuin activation and related complications in T2DM. This review summarizes the role as well as mechanism of sirtuins in the regulation of oxidative stress in T2DM and available drugs targeting sirtuins in clinic, which may provide novel insights into the mechanism and therapy of T2DM.
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